Topic outline
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The CBE facility is a self-contained, Containment Level 2 Laboratory Unit.The CBE Laboratory Unit is a shared multi-user facility. The primary purpose of the Unit is translational research aimed at the generation of new medical therapies and healthcare technologies with a particular focus on manufacturing and bioprocessing.
Much of the work in the Unit involves biological material. The Unit has therefore been designed as a controlled environment and operates under a Quality Management System to both be compliant to the necessary regulations, to ensure research quality and relevance and to protect research materials
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Please complete the checklist ahead of you leaving the university to ensure all handovers have been completed.
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Please use this checklist for guidance to help you when you first join the CBE team
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The CBE has a wide variety of different equipment and systems which will alarm if an issue or fault is detected.
The attached gives a summary of the types of alarm in the CBE and how you should respond to them.
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All the information you need can be found at:
https://www.lboro.ac.uk/services/hr/support/occupational-health/
Sarah van Zoelen
Occupational Health and Wellbeing Manager
Sarah Sargeant
Occupational Health and Wellbeing Administrator
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52.4 KB Excel 2007 spreadsheet
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Information on Biosafety and Biological Safety Cabinets.
In the CBE we have two types of BSC's Ducted and recirculatory.
Different Class II cabinets have different means of cabinet exhaust. Some cabinets
may exhaust filtered air directly back to the laboratory, while others may exhaust air through a
dedicated ductwork system to the external environment
A biosafety cabinet (BSC)—also called a biological safety cabinet or microbiological safety cabinet—is an enclosed, ventilated laboratory workspace for safely working with materials contaminated with (or potentially contaminated with) pathogens requiring a defined biosafety level.
The primary purpose of a BSC is to serve as a means to protect the laboratory worker and the surrounding environment from pathogens. All exhaust air is HEPA-filtered as it exits the biosafety cabinet, removing harmful bacteria and viruses.[2] ] However, most classes of BSCs have a secondary purpose to maintain the sterility of materials inside (the "product").
Principles of operation use motor driven blowers (fans) mounted in the cabinet to draw directional mass airflow around a user and into the air grille - protecting the operator. The air is then drawn underneath the work surface and back up to the top of the cabinet where it passes through the HEPA filters. A column of HEPA filtered, sterile air is also blown downward, over products and processes to prevent contamination. Air is also exhausted through a HEPA filter, and depending on the Type of Class II BSC, the air is either recirculated back into the laboratory or pulled by an exhaust fan, through ductwork where it is expelled from the building
Managing Containment laboratories